Characterization of an influenza A H5N2 reassortant as a candidate for live-attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential
Identifieur interne : 001569 ( Main/Exploration ); précédent : 001568; suivant : 001570Characterization of an influenza A H5N2 reassortant as a candidate for live-attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential
Auteurs : J. A. Desheva [Russie] ; X. H. Lu [États-Unis] ; A. R. Rekstin [Russie] ; L. G. Rudenko [Russie] ; D. E. Swayne [États-Unis] ; N. J. Cox [États-Unis] ; J. M. Katz [États-Unis] ; A. I. Klimov [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Anticorps antiviraux (immunologie), Femelle, Flambées de maladies, Grippe chez les oiseaux (), Grippe chez les oiseaux (immunologie), Grippe humaine (), Grippe humaine (immunologie), Humains, Immunisation, Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Poulets (immunologie), Réactions croisées, Réplication virale, Souris, Souris de lignée BALB C, Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (pathogénicité), Sous-type H5N2 du virus de la grippe A (immunologie), Tests de neutralisation, Vaccins antigrippaux (immunologie), Vaccins atténués (immunologie), Vaccins inactivés (immunologie).
- MESH :
- biosynthèse : Anticorps antiviraux.
- immunologie : Anticorps antiviraux, Grippe chez les oiseaux, Grippe humaine, Infections à Orthomyxoviridae, Poulets, Sous-type H5N1 du virus de la grippe A, Sous-type H5N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Vaccins inactivés.
- pathogénicité : Sous-type H5N1 du virus de la grippe A.
- virologie : Infections à Orthomyxoviridae.
- Pascal (Inist)
- Animaux, Femelle, Flambées de maladies, Grippe chez les oiseaux, Grippe humaine, Humains, Immunisation, Réactions croisées, Réplication virale, Souche atténuée, Souris, Souris de lignée BALB C, Tests de neutralisation, Vaccin, Pouvoir pathogène, Modèle animal, Grippe A, Réassortiment génétique, Grippe aviaire.
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
- Animal model, Animals, Antibodies, Viral (biosynthesis), Antibodies, Viral (immunology), Attenuated strain, Avian influenza, Chickens (immunology), Cross Reactions, Disease Outbreaks, Female, Genetic reassortment, Humans, Immunization, Influenza A, Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza A Virus, H5N2 Subtype (immunology), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (prevention & control), Influenza, Human (immunology), Influenza, Human (prevention & control), Mice, Mice, Inbred BALB C, Neutralization Tests, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Pathogenicity, Vaccine, Vaccines, Attenuated (immunology), Vaccines, Inactivated (immunology), Virus Replication.
- MESH :
- chemical , biosynthesis : Antibodies, Viral.
- chemical , immunology : Antibodies, Viral, Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- immunology : Chickens, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H5N2 Subtype, Influenza in Birds, Influenza, Human, Orthomyxoviridae Infections.
- pathogenicity : Influenza A Virus, H5N1 Subtype.
- prevention & control : Influenza in Birds, Influenza, Human.
- virology : Orthomyxoviridae Infections.
- Animals, Cross Reactions, Disease Outbreaks, Female, Humans, Immunization, Mice, Mice, Inbred BALB C, Neutralization Tests, Virus Replication.
Abstract
We generated a high-growth 7:1 reassortant (Lenl7/H5) that contained the hemagglutinin (HA) gene from non-pathogenic A/Duck/Potsdam/1402-6/86 (H5N2) virus and other genes from the cold-adapted (ca) attenuated A/Leningrad/134/17/57 (H2H2) strain. Lenl7/H5 demonstrated an attenuated phenotype in mice and did not infect chickens. Mice administered Lenl7/H5 either as a live-attenuated intranasal vaccine or as an inactivated intramuscular vaccine were substantially protected from lethal challenge with highly pathogenic A/Hong Kong/483/97 (H5N1) virus and were protected from pulmonary infection with antigenically distinct A/Hong Kong/213/2003 (H5N1) virus. The cross-protective effect correlated with the levels of virus-specific mucosal IgA and/or serum IgG antibodies. Our results suggest a new strategy of using classical genetic reassortment between a high-growth ca H2N2 strain and antigenically related non-pathogenic avian viruses to prepare live-attenuated and inactivated vaccines for influenza pandemic. Published by Elsevier Ltd.
Affiliations:
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Lu</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Influenza Branch, Centers for Diseases Control and Prevention, 1600 Clifton Rd., NE</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A. R." last="Rekstin">A. R. Rekstin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Institute of Experimental Medicine, RAMS</s1><s2>St. Petersburg</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Russie</country><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. 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Cox</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Influenza Branch, Centers for Diseases Control and Prevention, 1600 Clifton Rd., NE</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Katz, J M" sort="Katz, J M" uniqKey="Katz J" first="J. M." last="Katz">J. M. Katz</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Influenza Branch, Centers for Diseases Control and Prevention, 1600 Clifton Rd., NE</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A. I." last="Klimov">A. I. 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A." last="Desheva">J. A. Desheva</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Institute of Experimental Medicine, RAMS</s1><s2>St. Petersburg</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Russie</country><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Lu, X H" sort="Lu, X H" uniqKey="Lu X" first="X. H." last="Lu">X. H. Lu</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Influenza Branch, Centers for Diseases Control and Prevention, 1600 Clifton Rd., NE</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A. R." last="Rekstin">A. R. Rekstin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Institute of Experimental Medicine, RAMS</s1><s2>St. Petersburg</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Russie</country><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Institute of Experimental Medicine, RAMS</s1><s2>St. Petersburg</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Russie</country><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Swayne, D E" sort="Swayne, D E" uniqKey="Swayne D" first="D. E." last="Swayne">D. E. Swayne</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Southeast Poultry Research Laboratory, US Department of Agriculture, Agriculture Research Service</s1><s2>Athens, GA 30605</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cox, N J" sort="Cox, N J" uniqKey="Cox N" first="N. J." last="Cox">N. J. Cox</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Influenza Branch, Centers for Diseases Control and Prevention, 1600 Clifton Rd., NE</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Katz, J M" sort="Katz, J M" uniqKey="Katz J" first="J. M." last="Katz">J. M. Katz</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Influenza Branch, Centers for Diseases Control and Prevention, 1600 Clifton Rd., NE</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A. I." last="Klimov">A. I. Klimov</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Influenza Branch, Centers for Diseases Control and Prevention, 1600 Clifton Rd., NE</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Animals</term><term>Antibodies, Viral (biosynthesis)</term><term>Antibodies, Viral (immunology)</term><term>Attenuated strain</term><term>Avian influenza</term><term>Chickens (immunology)</term><term>Cross Reactions</term><term>Disease Outbreaks</term><term>Female</term><term>Genetic reassortment</term><term>Humans</term><term>Immunization</term><term>Influenza A</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term><term>Influenza A Virus, H5N2 Subtype (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Influenza in Birds (immunology)</term><term>Influenza in Birds (prevention & control)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (virology)</term><term>Pathogenicity</term><term>Vaccine</term><term>Vaccines, Attenuated (immunology)</term><term>Vaccines, Inactivated (immunology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Anticorps antiviraux (immunologie)</term><term>Femelle</term><term>Flambées de maladies</term><term>Grippe chez les oiseaux ()</term><term>Grippe chez les oiseaux (immunologie)</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Immunisation</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Poulets (immunologie)</term><term>Réactions croisées</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term><term>Sous-type H5N2 du virus de la grippe A (immunologie)</term><term>Tests de neutralisation</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (immunologie)</term><term>Vaccins inactivés (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term><term>Poulets</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Sous-type H5N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Chickens</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A Virus, H5N2 Subtype</term><term>Influenza in Birds</term><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cross Reactions</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Immunization</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Virus Replication</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Flambées de maladies</term><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Humains</term><term>Immunisation</term><term>Réactions croisées</term><term>Réplication virale</term><term>Souche atténuée</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term><term>Vaccin</term><term>Pouvoir pathogène</term><term>Modèle animal</term><term>Grippe A</term><term>Réassortiment génétique</term><term>Grippe aviaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We generated a high-growth 7:1 reassortant (Lenl7/H5) that contained the hemagglutinin (HA) gene from non-pathogenic A/Duck/Potsdam/1402-6/86 (H5N2) virus and other genes from the cold-adapted (ca) attenuated A/Leningrad/134/17/57 (H2H2) strain. Lenl7/H5 demonstrated an attenuated phenotype in mice and did not infect chickens. Mice administered Lenl7/H5 either as a live-attenuated intranasal vaccine or as an inactivated intramuscular vaccine were substantially protected from lethal challenge with highly pathogenic A/Hong Kong/483/97 (H5N1) virus and were protected from pulmonary infection with antigenically distinct A/Hong Kong/213/2003 (H5N1) virus. The cross-protective effect correlated with the levels of virus-specific mucosal IgA and/or serum IgG antibodies. Our results suggest a new strategy of using classical genetic reassortment between a high-growth ca H2N2 strain and antigenically related non-pathogenic avian viruses to prepare live-attenuated and inactivated vaccines for influenza pandemic. Published by Elsevier Ltd.</div></front></TEI><affiliations><list><country><li>Russie</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Russie"><noRegion><name sortKey="Desheva, J A" sort="Desheva, J A" uniqKey="Desheva J" first="J. A." last="Desheva">J. A. Desheva</name></noRegion><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A. R." last="Rekstin">A. R. Rekstin</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Lu, X H" sort="Lu, X H" uniqKey="Lu X" first="X. H." last="Lu">X. H. Lu</name></region><name sortKey="Cox, N J" sort="Cox, N J" uniqKey="Cox N" first="N. J." last="Cox">N. J. Cox</name><name sortKey="Katz, J M" sort="Katz, J M" uniqKey="Katz J" first="J. M." last="Katz">J. M. Katz</name><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A. I." last="Klimov">A. I. Klimov</name><name sortKey="Swayne, D E" sort="Swayne, D E" uniqKey="Swayne D" first="D. E." last="Swayne">D. E. Swayne</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:07-0016146
|texte= Characterization of an influenza A H5N2 reassortant as a candidate for live-attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential
}}
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